Custom Peptides
Cayman Chemical 3-ChlorogentIsyl Alcohol 10mg
A phenol and microbial metabolite with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 1 µM); acitve against MRSA (MIC = 50 UG/ml); active against 13 Gram-positive and Gram-negative bacteria at 50 UG/disc; has concentration-dependent antifouling activity against barnacle cyprids in the conventional submerged assay using polystyrene plates in a concentration-dependent manner; induces apoptosis and cell cycle arrest at the S phase in HeLa cancer cells at 50 µM; induces ssDNA breaks in a comet assay using HeLa cells at 35 µM
Cayman Chemical 1-MSHhumnmouseratbo 10mg
A peptide hormone; selectively binds to MC1R and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM); inhibits FMRF-amide-induced contractions in isolated M. edulis catch muscle at 10 µM; intracisternal administration increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice at 0.3 nmol/animal; inhibits LPS-induced NO release in mouse forebrain in vivo at 0.01 nmol/animal
Cayman Chemical SaroglItazar MagnsIum 10mg
A PPARα and PPARγ dual agonist (EC50s = 0.65 and 3,000 pM, respectively); decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes at 0.01-3 mg/kg; increases insulin sensitivity in an oral glucose challenge at 1 mg/kg; reverses palmitic acid-induced decreases in the expression of mRNA encoding SOD1, SOD2, GPX, and catalase and increases in the expression of mRNA encoding TNF-α, IL-1β, and IL-6 in HepG2 cells at 10 µM; decreases hepatic inflammation and steatosis in a mouse model of NASH induced by a choline-deficient high-fat diet at 3 mg/kg
Cayman Chemical DIhydrocurcumIn 10mg
An active metabolite of curcumin; reduces triglyceride levels and increases glucose uptake in HepG2 and L-02 cellular models of oleic acid-induced steatosis at 20 µM
Cayman Chemical BelotecnhydrochlorIde 10mg
A DNA topoisomerase I inhibitor (IC50 = 0.119 UG/ml); a derivative of camptothecin; inhibits the proliferation of KATO III, HT-29, A549, MDA-MB-231, and SKOV3 cells (IC50s = 160, 10.9, 9, 345, and 31 ng/ml, respectively); induces apoptosis and cell cycle arrest at the G2/M phase in, and inhibits invasion of, SiHa cells at 150 ng/ml; reduces tumor growth in a Ca Ski cervical cancer mouse xenograft model at 25 mg/kg; reduces food intake and body weight in pregnant dams and increases fetal deaths and decreases litter size at 80 UG/kg
Cayman Chemical AcalabrutInIb 10mg
An irreversible BTK inhibitor; dose-dependently inhibits B cell receptor signaling in primary CLL cells
Cayman Chemical JWH 018 N 2 2dImthylPRYl 10mg
Differs from JWH 018 structurally by having a 2,2-dimethylpropyl group, rather than a pentyl chain, extending from the indole group; intended for research and forensic applications
Cayman Chemical 4mthylaPyrroldInobutIoph 10mg
A synthetic cathinone with psychoactive properties which has recently been identified in party pills and powders; intended for forensic and research applications
Cayman Chemical RJR 2429hydrochlorIde 10mg
An agonist of nicotinic AChRs; selective for α4β2 or α7 subunit-containing nicotinic AChRs (Kis = 0.7 and 10.9 nM in isolated rat cortex and isolated rat hippocampus, respectively) over α1βɣδ subunit-containing nicotinic AChRs (EC50 = 1,000 nM in PC12 cells); induces dopamine release from isolated rat striatal synaptosomes (EC50 = 2.4 nM) and increases nicotine-induced elevations in epinephrine and norepinephrine levels in isolated rat adrenal gland at 100 µM; inhibits nicotine-induced ion flux in isolated rat thalamic synaptosomes (IC50 = 154 nM)
Cayman Chemical StrontIum Rnlate 10mg
An antiosteoporotic agent; inhibits 1,25-dihydroxyvitamin D3-induced increases in the levels of carbonic anhydrase II and the vitronectin receptor, markers of osteoclast differentiation, in isolated chicken bone marrow cells at 0.1, 0.5, and 1 mM; pretreatment or continuous treatment of bovine bone slices at 1 mM inhibits bone resorption by isolated rat osteoclasts; decreases osteoclast surface and number but has no effect on the bone formation rate or mineral apposition rate in the alveolar bone in adult cynomolgus monkeys at 750 mg/kg per day
Cayman Chemical Garcnon D 10mg
A xanthone with diverse biological activities; increases proliferation of C17.2 NPCs at 5 µM; inhibits aggregation of Aβ42 in vitro at 3 µM and inhibits BACE1 by 62.7% at 100 µM; scavenges peroxynitrite radicals (IC50 = 26.4 µM)
Cayman Chemical DeltrphIn CtrIfluoroACTAt 10mg
A peptide agonist of δ-opioid receptors (Ki = 0.15 nM); selective for δ-opioid receptors over µ- and ĸ-opioid receptors; induces δ-opioid receptor translocation from large dense-core vesicles to the cell surface and CGRP release in isolated mouse DRG cells at 0.1 and 1 µM, respectively; increases latency to withdraw in the paw pressure and tail-flick tests in rats at 0.15, 1.5, and 15 UG/animal intrathecally
Cayman Chemical NCS-382sodIum salt 10mg
A GHBR antagonist (IC50s = 134.1 and 201.3 nM in isolated rat striatal and hippocampal membranes, respectively, in radioligand binding assays); selective for GHBR over GABA binding sites in rat brain synaptic membranes at 1 and 10 µM; decreases GHB-induced increases in inositol phosphate accumulation and cGMP levels in isolated rat hippocampal slices (IC50s = 8.6 and 30 µM, respectively); reduces GHB-induced increases in the time mice spent immobile in the forced swim test at 1.66 and 2.08 mmol/kg; decreases spike and wave discharges in audiogenic seizure-susceptible Swiss Rb mice, as well as a rat model of petit mal epilepsy, at 2.3 mmol/kg
Cayman Chemical ReparIxInL-LysIn salt 10mg
A non-competitive allosteric inhibitor of IL-8/CXCL8 activation of CXCR1 and CXCR2 chemokine receptors (IC50s = 1 and 100 nM, respectively); blocks IL-8-induced leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists; at 100 nM, depletes a cancer stem cell population in human breast cancer cell lines in vitro